| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9769190 | European Journal of Medicinal Chemistry | 2005 | 6 Pages |
Abstract
Spiro derivatives of oxindole and isoxazole-5-one were synthesized by using Michael addition reaction, highlighting the regioselective approach towards the synthesis of Michael diadduct followed by condensation of Michael diadduct. The spiro compound 4 showed antitubercular activity against Mycobacterium tuberculosis H37Rv whereas spiro compound 9 possesses pronounced anticancer and antibacterial profile.
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Authors
Madhukar S. Chande, Ranjit S. Verma, Pravin A. Barve, Rahul R. Khanwelkar, R.B. Vaidya, K.B. Ajaikumar,