Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9769221 | European Journal of Medicinal Chemistry | 2005 | 13 Pages |
Abstract
We previously reported the synthesis and biological activity of novel substituted pyridines and purines having thiazolidinedione with hypoglycemic and hypolipidemic activities. We now report the synthesis and antidiabetic activity of novel substituted pyrimidines having thiazolidinedione moiety. These compounds (entry No. 5a-i, 10a-d and 16) were evaluated for their glucose and lipid lowering activity in KKAy mice. From the results, novel compounds, 5c and 5g, exhibited considerably more potent biological activity than that of the reference compounds, pioglitazone and rosiglitazone, respectively.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hong Woo Lee, Bok Young Kim, Joong Bok Ahn, Sung Kwon Kang, Jung Hwa Lee, Jae Soo Shin, Soon Kil Ahn, Sang Joon Lee, Seung Soo Yoon,