Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9769252 | European Journal of Medicinal Chemistry | 2005 | 7 Pages |
Abstract
The introduction of side chains bearing epoxide motifs into the molecular scaffold of kenpaullone and 9-trifluoromethylpaullone led to improved antiproliferative activity of the novel derivatives for human tumor cell lines. The syntheses were accomplished applying Stille coupling for the introduction of unsaturated side chains into the 2-position of the paullones and subsequently employing a hydrogen peroxide/nitrile mixture for the epoxidation of C,C-double bonds.
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Authors
Xu Xie, Thomas Lemcke, Rick Gussio, Daniel W. Zaharevitz, Maryse Leost, Laurent Meijer, Conrad Kunick,