| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9769262 | European Journal of Medicinal Chemistry | 2005 | 13 Pages |
Abstract
A series of combretastatins substituted with epoxides, amides and small alkyl groups has been synthesised and evaluated for cytotoxicity and their ability to inhibit the assembly of tubulin. The methyl and ethyl substituted phenols 36, 44 have shown potent antimitotic effects whilst exhibiting reduced cytotoxicity.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
John A. Hadfield, Keira Gaukroger, Nicholas Hirst, Anna P. Weston, Nicholas J. Lawrence, Alan T. McGown,