Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9769274 | European Journal of Medicinal Chemistry | 2005 | 7 Pages |
Abstract
We describe the synthesis and activities of a series of pseudopeptides containing an N-aryl-Nâ²-hydroxyalkyl hydrazide core structure to inhibit human immunodeficiency virus protease and viral replication. Of the series, compound Hmb-Leu-N(Bzl)-N(CH2-CH-OH)-rPro-Boc (24) displayed the greatest inhibitory potency (IC50 < 1 μM) and exhibited enzymatic resistance and stability in vitro.
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Authors
M. Marastoni, A. Baldisserotto, C. Trapella, J. McDonald, F. Bortolotti, R. Tomatis,