Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9769292 | European Journal of Medicinal Chemistry | 2005 | 8 Pages |
Abstract
The six novel 4-methylcoumarins bearing different functionalities such as amino, hydroxy, N-acetyl, acetoxy and nitro have been synthesized and confirmed on the basis of their spectral data (1H-, 13C-NMR, UV, IR and EI mass). They were examined for the first time for their effect on NADPH dependent liver microsomal lipid peroxidation in vitro, and the results were compared with other model 4-methylcoumarin derivatives to establish the structure-activity relationship. Our studies demonstrated that amino group is an effective substitute for the hydroxyl group for antioxidant property and produced a dramatic inhibition of lipid peroxidation. Ortho dihydroxy and ortho hydroxy-amino coumarins were found to possess highest antioxidant and radical scavenging activities.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yogesh K. Tyagi, Ajit Kumar, Hanumantharao G. Raj, Parag Vohra, Garima Gupta, Ranju Kumari, Pankaj Kumar, Rajinder K. Gupta,