Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9774613 | Journal of Controlled Release | 2005 | 7 Pages |
Abstract
A one-step, mild procedure based on coaxial electrospinning was developed for incorporation and controlled release of two model proteins, BSA and lysozyme, from biodegradable core-shell nanofibers with PCL as shell and protein-containing PEG as core. The thickness of the core and shell could be adjusted by the feed rate of the inner dope, which in turn affected the release profiles of the incorporated proteins. It was revealed that the released lysozyme maintained its structure and bioactivity. The current method may find wide applications for controlled release of proteins and tissue engineering.
Related Topics
Physical Sciences and Engineering
Materials Science
Biomaterials
Authors
Hongliang Jiang, Yingqian Hu, Yan Li, Pengcheng Zhao, Kangjie Zhu, Weiliam Chen,