Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9774657 | Journal of Controlled Release | 2005 | 8 Pages |
Abstract
A drug delivery micrcoelectromechanical systems (MEMS) device was used to locally deliver a chemotherapeutic agent (BCNU) to an experimental tumor in rats. This MEMS device consists of an array of reservoirs etched into the silicon substrate. The drug release is achieved by the electrochemical dissolution of the gold membranes covering the reservoirs. A new Pyrex package was developed to improve the BCNU release kinetics and enhance device capacity. Co-formulation of BCNU with polyethylene glycol (PEG) led to complete and rapid release of drug in vivo. BCNU delivered from the MEMS device showed dose-dependent inhibiting effect on the tumor growth in the BCNU dosage range of 0.67â¼2 mg. BCNU delivered from the activated devices was as effective as equipotent subcutaneous injections of BCNU in inhibiting tumor growth. Further optimization using this MEMS device to deliver BCNU in combination with other therapeutic agents against the tumor challenge is possible because of the unique capability of the device to precisely control the temporal release profiles of multiple substances.
Related Topics
Physical Sciences and Engineering
Materials Science
Biomaterials
Authors
Yawen Li, Hong Linh Ho Duc Hong Linh Ho Duc, Betty Tyler, Tiffany Williams, Malinda Tupper, Robert Langer, Henry Brem, Michael J. Cima,