Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9783129 | Materials Chemistry and Physics | 2005 | 6 Pages |
Abstract
Poly(N-vinyl-2-pyrrolidone) (PVP) is widely used in medicine due to its high biocompatibility. In this study, itaconic acid (IA) was co-polymerized with N-vinyl-2-pyrrolidone (NVP) monomer to prepare the pH sensitive hydrogels. These copolymer hydrogels were prepared using ultra-violet (UV) induced methods at ambient temperature. Monomer and cross-linking agent (N,Nâ²-methylene-bisacrylamide (MBAAm)) concentration effects on preparation of this copolymer hydrogel were investigated using swelling, FT-IR, and SEM. The prepared copolymer hydrogel is highly pH sensitive. The percentage swell of the copolymer hydrogels was found to increase from 150 to 3011% as the pH value of the swelling solution varied from 4 to 10. These pH sensitive copolymer hydrogels present a promising approach for drug delivery applications.
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Authors
Ko-Shao Chen, Yuan-An Ku, Hong-Ru Lin, Tsong-Rong Yan, Dey-Chyi Sheu, Tim-Mo Chen, Feng-Huei Lin,