Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9801370 | Science and Technology of Advanced Materials | 2005 | 5 Pages |
Abstract
A hydrotropic dendrimer, made of polyglycerol dendrimer of generation 4 (PGD-G4), was conjugated with cholesterol. The self-assembled structure of the conjugate in water was characterized by 1H-NMR, dynamic light scattering (DLS) and atomic force microscopy (AFM). One cholesterol molecule was conjugated to PGD-G4, which was confirmed by MALDI-TOF mass spectroscopy. The DLS analysis showed that the conjugate formed self-assembly with a diameter of 49.9-59.9Â nm. The AFM image suggests that the self-assembly is a micelle-like sphere. The level of paclitaxel solubilization by the conjugate in water was similar to that of PGD-G4 itself, and this suggests that the PGD-G4 is located on the outer part of the self-assembly to function as a hydrotrope.
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Authors
Tooru Ooya, Kang Moo Huh, Masato Saitoh, Eiichi Tamiya, Kinam Park,