The results of postoperative irradiation in malignant glioma patients

The prognosis for high-grade glioma patients remains poor. The combined treatment, operation and radiotherapy, resulted in the overall survival of 0.38 at one year and 0.13 at two years and the progression free survival of 0.13 at one year and 0.06 at two years in the study group. In the multivariate analysis: histopathology, age, performance and the neurological status before the onset of radiotherapy, the total dose of the irradiation and the response to treatment observed three months from the end of radiotherapy were found to be significant prognostic factors influencing the overall survival, while histopathology, age, performance and the neurological status at the beginning of the irradiation, the total dose of radiotherapy were found to be significant prognostic factors influencing the progression free survival. The assessment of the prognostic factors is very important, because it is a guide to the treatment selection by clinicians.