Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9872039 | International Journal of Radiation Oncology*Biology*Physics | 2005 | 7 Pages |
Abstract
Conclusion: These data indicate that PI3K inhibition increases sensitivity of prostate cancer cell lines to ionizing radiation through inactivation of PKB. Therefore, PTEN mutations, which lead to PKB activation, may play an important role in the resistance of prostate cancer to radiation therapy. Targeted therapy against PKB could be beneficial in the management of prostate cancer patients.
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
Alexander R. M.D., Ph.D., Albert B.S., Jean L. M.D., David Ph.D., Daphne A. M.D.,