Can histopathologic assessment of circumferential margin after preoperative pelvic chemoradiotherapy for T3-T4 rectal cancer predict for 3-year disease-free survival?

Article ID	Journal	Published Year	Pages	File Type
9872062	International Journal of Radiation OncologyBiologyPhysics	2005	8 Pages	PDF

Abstract

Conclusion: After 5-fluorouracil-based CRT, a positive CRM predicted for a high risk of subsequent local recurrence and a 3-year disease-free survival rate of only 9%. For this reason, the CRM should be considered a major prognostic factor and should be validated in future trials as an early alternative clinical endpoint.

Keywords

Tumor downstaging Rectal adenocarcinoma Preoperative chemoradiotherapy Prognostic factors Circumferential resection margin

Related Topics

Physical Sciences and Engineering Physics and Astronomy Radiation

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Can histopathologic assessment of circumferential margin after preoperative pelvic chemoradiotherapy for T3-T4 rectal cancer predict for 3-year disease-free survival?

Authors

Suzannah (F.R.C.R.), Rob (F.R.C.P., F.R.C.R.), Juliet Grainger, Paul (F.R.C.Path.), Andreas (F.R.C.R.), Mark (F.R.C.R.), Richard (F.R.C.R.), Richard A. (F.R.C.S.), Melanie (F.R.C.R.), Jeremy I. (F.R.C.S.), Peter (F.R.C.S.), Ian C. (F.R.C.S.),