Biophysical analysis of the acute toxicity of radiotherapy in Hodgkin's lymphoma-a comparison between extended field and involved field radiotherapy based on the data of the German Hodgkin Study Group

Conclusion Radiotherapy volume reduction from extended field to involved field after two cycles of COPP/ABVD chemotherapy gives similar results and less toxicity in patients with early-stage, unfavorable HL. Biophysical parameters could be determined from the complication probability data after RT of HL. Because of the exponential dependence, this biophysical model is unstable. It represents a “start model” until further data can be incorporated.