Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9872124 | International Journal of Radiation Oncology*Biology*Physics | 2005 | 9 Pages |
Abstract
Conclusions: These data demonstrate that the biologic effects of 2 Gy may differ in different clinical settings depending on the size and sequence of the partial fractions. The variation between cytotoxic effects is likely a result of the combination of low-dose hyper-radiosensitivity (HRS) and higher-dose increased radioresistance (IRR) effects established recently. We suggest that to ensure the optimal biologic effect of a prescribed dose of 2 Gy clinically, it is critical to consider the sequence in which the treatment fields are delivered when partial fractions of different sizes are used.
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Radiation
Authors
Peck-Sun Ph.D., Andrew Ph.D.,