Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9872303 | International Journal of Radiation Oncology*Biology*Physics | 2005 | 10 Pages |
Abstract
Conclusions: Accelerated hypofractionated pelvic EBRT integrated with TRUS-guided conformally modulated HDR administered to 1,260 patients in three institutions was an excellent method of delivering very high radiation dose to the prostate in 5 weeks. Similar high overall, cause-specific, and biochemical no evidence of disease survival rates achieved show that prostate HDR can be successfully delivered in academic and community settings. At 8 years, the addition of a course of â¤6 months of neoadjuvant/concurrent androgen deprivation therapy to a very high radiation dose did not confer a therapeutic advantage but added side effects and cost. Furthermore, for the most unfavorable group, there was a higher rate of distant metastasis and more prostate cancer-related deaths. We question the value of a short course of androgen deprivation therapy when used with high-dose radiation.
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Authors
Alvaro A. (F.A.C.R.), D. Jeffrey M.D., Razvan M.D., Carlos M.D., Hagen M.D., Rodney M.D., Gary M.D., Gillian M.D., Jose M.D.,