Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9872372 | International Journal of Radiation Oncology*Biology*Physics | 2005 | 11 Pages |
Abstract
Conclusions: Motexafin gadolinium plus AA generated ROS, which in turn altered GSH homeostasis and induced DNA strand breaks. The MGd plus AA-mediated alteration of GSH levels increased the hypoxic, but not aerobic, radiosensitivity of EMT6 cells. Motexafin gadolinium altered the kinetics of single-strand break repair soon after irradiation but did not inhibit potentially lethal damage repair in EMT6 cells.
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Authors
Erling T. Ph.D., Yanfeng M.S., Tracy K. Paul, Sara Ph.D.,