Article ID Journal Published Year Pages File Type
9872372 International Journal of Radiation Oncology*Biology*Physics 2005 11 Pages PDF
Abstract
Conclusions: Motexafin gadolinium plus AA generated ROS, which in turn altered GSH homeostasis and induced DNA strand breaks. The MGd plus AA-mediated alteration of GSH levels increased the hypoxic, but not aerobic, radiosensitivity of EMT6 cells. Motexafin gadolinium altered the kinetics of single-strand break repair soon after irradiation but did not inhibit potentially lethal damage repair in EMT6 cells.
Related Topics
Physical Sciences and Engineering Physics and Astronomy Radiation
Authors
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