Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9872373 | International Journal of Radiation Oncology*Biology*Physics | 2005 | 8 Pages |
Abstract
Conclusions: The most probable mechanism of action, explaining the enigmatic high radiosensitivity for early effects, is selective radiation damage to the plasma membrane of the secretory cells, disturbing muscarinic receptor stimulated watery secretion. Later damage is mainly due to classical mitotic cell death of progenitor cells, leading to a hampered replacement capacity of the gland for secretory cells, but is also caused by damage to the extracellular environment, preventing proper cell functioning.
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
Antonius W.T. Ph.D., Rob P. Ph.D., Arjan D.M.D., M.D., Ph.D.,