Increased oxygenation of intracranial tumors by efaproxyn (efaproxiral), an allosteric hemoglobin modifier: In vivo EPR oximetry study

Conclusion: We obtained quantitative data on the timing and extent of efaproxiral-induced changes in the pO2 of intracerebral 9L tumors. These results illustrate a unique and useful capability of in vivo EPR oximetry to obtain repeated noninvasive measurements of tumor oxygenation over a number of days. The information on the dynamics of tumor pO2 after efaproxiral administration illustrates the ability of efaproxiral to increase intracranial tumor oxygenation.