Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9872717 | International Journal of Radiation Oncology*Biology*Physics | 2005 | 12 Pages |
Abstract
The dual parameter model containing pHi and T2 to predict the pCR in STSs treated with thermoradiotherapy was not verified. However, other parameters were statistically significant, including the PDE/Pi ratio and hypoxic fraction. These relationships may have interfered with our ability to obtain the pCR rate predicted by thermal doses achieved in these patients. The relationship between the PME/PDE ratio and metastasis-free and overall survival was provocative, but requires additional study to verify its predictive capability. Currently, 50% of all STS patients with high-grade tumors develop distant metastasis even when excellent local control is achieved. Parameters that could help select for patients who need adjuvant chemotherapy could have significant clinical benefit.
Keywords
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
Mark W. D.V.M., Ph.D., Jean M. D.V.M., Ph.D., Daohai Ph.D., Linda M.S., Michaël D.V.M., Zeljko M.D., Ph.D., Ellen L. M.D., Thaddeus V. Ph.D., Barbara E. D.V.M., Ph.D., David M. M.D., Leonard R. M.D., H. Cecil Ph.D.,