| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9872774 | International Journal of Radiation Oncology*Biology*Physics | 2005 | 8 Pages |
Abstract
The sensitivity of cells to β-lap is dependent on NQO1 activity. IR caused a long-lasting increase in NQO1 activity in cancer cells, thereby sensitizing cells to β-lap and treatment of experimental mouse tumors with IR and β-lap suppressed tumor growth in a synergistic manner. The combination of β-lap and radiotherapy is a potentially effective regimen for the treatment of human cancer.
Keywords
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
Heon Joo M.D., Ph.D., Ki-Jung M.D., Seung-Do M.D., Eunkyung M.D., Ph.D., Sang Wook M.D., Brent B.S., Eun Jung B.S., Robert Ph.D., Erik A. Ph.D., William G. Ph.D., Jinming Ph.D., Heon Jin Ph.D., David A. Ph.D., Chang W. Ph.D.,