Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9879476 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2005 | 8 Pages |
Abstract
β-carotene is the major carotenoid occurring in the human diet and in the human organism. Besides its function as pro-vitamin A, β-carotene has been shown to be an activator of the human pregnan X receptor (PXR). PXR is mainly expressed in the liver/intestine and an inducer of enzymes involved in phase I, II and III metabolism. This review is focused on the evaluation of physiological and nutritional relevance of β-carotene as an inducer of phase I enzymes in the human organism via PXR-mediated mechanisms. Beneficial and detrimental effects of β-carotene on xenobiotica metabolism and metabolism of various other derivatives will be discussed.
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Authors
Ralph Rühl,