| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9879515 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2005 | 12 Pages |
Abstract
New methods for analyzing tau fibrillization have yielded insights into the biochemical transitions involved in the process. Here we review the parallels between the sequential progression of tau fibrillization observed macroscopically in Alzheimer's disease (AD) lesions and the pathway of tau aggregation observed in vitro with purified tau preparations. In addition, pharmacological agents for further dissection of fibrillization mechanism and lesion formation are discussed.
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Authors
Jeff Kuret, Carmen N. Chirita, Erin E. Congdon, Theresa Kannanayakal, Guibin Li, Mihaela Necula, Haishan Yin, Qi Zhong,