Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9880330 | Journal of the Neurological Sciences | 2005 | 16 Pages |
Abstract
This review on the role of neurofilaments as surrogate markers for axonal degeneration in neurological diseases provides a brief background to protein synthesis, assembly, function and degeneration. Methodological techniques for quantification are described and a protein nomenclature is proposed. The relevance for recognising antineurofilament autoantibodies is noted. Pathological implications are discussed in view of immunocytochemical, cell-culture and genetic findings. With reference to the present symposium on multiple sclerosis, the current literature on body fluid levels of neurofilaments in demyelinating disease is summarised.
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Authors
Axel Petzold,