Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9881257 | Mechanisms of Ageing and Development | 2005 | 4 Pages |
Abstract
Although the limited replicative capacity of human fibroblasts in culture is frequently used as a model for aging, a question of major interest is whether the relationship between in vitro fibroblast proliferative capacity and species longevity is primary or secondary to a relationship with species body size. In this report we establish that body mass is the primary correlative of proliferative potential rather than species life-span.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Ageing
Authors
Antonello Lorenzini, Maria Tresini, Steven N. Austad, Vincent J. Cristofalo,