Article ID Journal Published Year Pages File Type
9881271 Mechanisms of Ageing and Development 2005 8 Pages PDF
Abstract
As has been experimentally determined, oxidative modification to biological systems can be extensive, although the identification and stochiometric relation of the reactive species that cause these alterations have not been fully elucidated. In this review, arguments are presented to support the notion that the combined effects of membrane lipid peroxidation and its by-products, reactive aldehydes are likely responsible for membrane-associated functional declines during aging. As evidence for a systemic response to overall oxidative stress, the molecular inflammation hypothesis of aging is discussed by considering that the activation of inflammatory genes act as a bridge linking normal aging to pathological processes.
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Ageing
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