Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9881397 | Mechanisms of Ageing and Development | 2005 | 6 Pages |
Abstract
The IUPS Physiome Project1 is an internationally collaborative open source project intended to provide a public domain framework for computational physiology, including the development of modeling standards, computational tools and web-accessible databases of models of structure and function at all spatial scales and across all organ systems. Here, we illustrate the application of this multi-scale modeling approach to three organ systems: the heart, the lungs and the musculo-skeletal system, and in each case we show how the organ level models incorporate tissue and cell-level physiology. Although the computational physiology framework presented here does not yet incorporate models of ageing processes, the model-based approach is certainly capable of describing ageing and disease-related processes both via parameter changes within the models of normal physiological processes and via models of additional processes added to the framework.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Ageing
Authors
Peter Hunter, Nicolas Smith, Justin Fernandez, Merryn Tawhai,