Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9904144 | Biology of Blood and Marrow Transplantation | 2005 | 9 Pages |
Abstract
We analyzed the outcomes of 24 consecutive patients aged â¥60 years with poor-prognosis myelodysplastic syndrome or acute myeloid leukemia undergoing transplantation with nonmyeloablative conditioning using fludarabine (125 mg/m2) and low-dose total body irradiation (2 Gy) followed by allogeneic peripheral blood stem cell grafts from HLA-identical sibling donors. Graft-versus-host disease (GVHD) prophylaxis consisted of cyclosporine and mycophenolate mofetil. The median age of the patients was 64 years (range, 60-71 years). In addition to age, 88% of patients had 1 or more adverse biological features of the disease. With a median follow-up of 21 months, 12 patients are alive, 11 of whom are disease free. The probabilities of 2-year overall and progression-free survival were 52% and 44%, respectively. The cumulative probabilities of relapse and of acute and chronic GVHD were 27%, 45%, and 74%, respectively. Nonrelapse mortality at 100 days and 2 years was 8% and 25%, respectively. Of the 15 patients with extensive chronic GVHD, 1 patient relapsed. These data suggest that nonmyeloablative stem cell transplantation is a feasible treatment option in patients aged â¥60 years with poor-prognosis myelodysplastic syndrome or acute myeloid leukemia. The reasonable disease control with nonmyeloablative transplantation in this high-risk group of patients merits further investigation.
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Authors
Vikas Gupta, Andrew Daly, Jeffrey H. Lipton, Wanda Hasegawa, Kathy Chun, Suzanne Kamel-Reid, Richard Tsang, Qi-long Yi, Mark Minden, Hans Messner, Thomas Kiss,