Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9905239 | Cancer Letters | 2005 | 8 Pages |
Abstract
Angiogenesis appears to be a fundamental requirement for tumor growth, invasion and metastasis. Evidence also exists to suggest that inhibition of tumor-associated angiogenesis can retard tumor growth and prevent tumor spread. Several naturally occurring angiogenesis inhibitors have been identified, including type I interferons (α/β). These proteins are potent inhibitors of angiogenesis and may also have direct anti-tumor and immunomodulatory effects. Because anti-angiogenic therapy is likely cytostatic, long-term delivery of angiogenesis inhibitors may be required for the successful treatment of cancer. We have, therefore, explored the utility of a gene therapy-mediated approach for the delivery of interferon-β and tested this approach, both alone and in combination with conventional chemotherapy, in murine models of neuroblastoma.
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Authors
Christian J. Streck, Catherine Y.C. Ng, Youbin Zhang, Junfang Zhou, Amit C. Nathwani, Andrew M. Davidoff,