Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9905267 | Cancer Letters | 2005 | 14 Pages |
Abstract
The Müllerian ducts are strongly influenced by natural estrogen, estradiol (E2) and diethylstilbestrol (DES) in their development. We screened E2 and DES responsive genes using a microarray analysis in human primitive Müllerian duct cell line, EMTOKA cells expressed estrogen receptor (ER) β. c-myc oncogene and other target genes expression was detected in cells treated by high-dose DES, but ER antagonist ICI 182,780 could not prevent c-myc induction above. Results of our present study suggested the presence of ER independent pathway in oncogenes induction process by high-dose DES treatment in a human primitive Müllerian duct cell line.
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Authors
Yasuhiro Miki, Takashi Suzuki, Chika Tazawa, Masato Ishizuka, Shuho Semba, Itsuo Gorai, Hironobu Sasano,