Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9905911 | European Journal of Cancer | 2005 | 10 Pages |
Abstract
Normal cells proliferate, die and differentiate as and when they should for the proper functioning of any particular tissue type. These processes are governed by a complex series of intracellular pathways that have many internal checkpoints and safety nets. These ensuring a fine, but tight, balance on overall tissue growth and distribution. A series of key aberrations, resulting in the disruption of these intracellular pathways, can lead to the development of a malignancy. The nature of these alterations is often not only tumour-specific, but also different between individuals with the same tumour type. As a result, these pathways have to be carefully dissected and functionally assessed to identify valid targets with therapeutic potential in a wide range of tumour types.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cancer Research
Authors
Helen S. Bell, Kevin M. Ryan,