| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9909100 | Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis | 2005 | 8 Pages |
Abstract
Heterozygous germ line defects in one of the MMR genes underlie the hereditary nonpolyposis colorectal cancer (HNPCC) syndrome. Based on the results described here we hypothesize that mutagen-induced loss of MMR in the intestine of these patients contributes to the tissue specificity of carcinogenesis in HNPCC patients.
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Authors
Viola Borgdorff, Sandrine van Hees-Stuivenberg, Caro M. Meijers, Niels de Wind,