| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9909189 | Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis | 2005 | 13 Pages |
Abstract
More investigations are needed to determine whether optimisation of cryopreservation protocol is possible to reduce these adverse effects; whether such mutations interfere with overall function of the cells; whether similar changes also occur in the nuclear DNA and whether such mutations happen in other species. Meanwhile, it is important to be cautious in making judgements of the effect of cryopreservation technique in assisted reproduction. This is the first report on the effect of cryopreservation on mtDNA.
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Authors
Julia Kopeika, Tiantian Zhang, David M. Rawson, Greg Elgar,