Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9910073 | Mutation Research/Genetic Toxicology and Environmental Mutagenesis | 2005 | 6 Pages |
Abstract
Compounds derived from 1,2,4-oxadiazole have being reported for their anti-inflamatory activity. However, those compounds should be devoid of any genotoxic side effect. In this work, the genotoxic activity of peptidomimetic moiety-containing 1,2,4-oxadiazoles derivatives was tested based on the Ames and SOS Chromotest. The results showed no mutagenic activity on the Ames test for 3-[3-phenyl-1,2,4-oxadiazol-5-yl] propionic acid (POPA) parental drug, but a weak SOS response induction on Chromotest. The chemical modifications reduced that response to a non-significative level, with l-phenylalanine peptidomimetic derivative being showing the lowest induction response. The results pointed out for the effectiveness of promoting chemical modifications of biological active compounds to increase its mode of action, showed in previous work, without increasing and even decreasing its DNA damage effect.
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Authors
Ana Cristina Lima Leite, Renata Freitas Fisher Vieira, Diogo Rodrigo de M. Moreira, Dalci Jose Brondani, Rajendra M. Srivastava, Verônica Freitas da Silva, Marcos Antônio de Morais Júnior,