Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9910129 | Mutation Research/Genetic Toxicology and Environmental Mutagenesis | 2005 | 7 Pages |
Abstract
Three doses of gemcitabine (0.001, 0.002 and 0.004 μg/ml) were applied to lymphocyte cultures from 15 donors. There was a significant increase in the induction of chromosome aberrations and in the occurrence of sister-chromatid exchange in these cells. In addition, gemcitabine significantly decreased the mitotic index and replicative index for all doses. Dose-response regression lines were used to compare the individual susceptibilities to gemcitabine with respect to the chromosome aberration and sister-chromatid exchange frequencies. Our results indicate that gemcitabine is able to induce both cytotoxic and genotoxic effects in human lymphocyte cultures in vitro in a dose-dependent manner.
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Authors
Nilüfer Aydemir, Serap Ãelikler, Rahmi BilaloÄlu,