Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9910165 | Mutation Research/Genetic Toxicology and Environmental Mutagenesis | 2005 | 4 Pages |
Abstract
The genotoxic effect of the herbicide paraquat was studied in rat bone-marrow by means of the micronucleus assay. Paraquat at dose levels of 6, 15 and 30Â mg/kg body weight was given to rats in a single application via the dermal route. Marrow was collected at 24, 48 and 72Â h after the application. The micronucleus assay was done as recommended by standard procedures. Paraquat gave rise to an increase in the number of micronuclei in a dose-dependent manner. The number of micronucleated polychromatic erythrocytes showed a maximum at 48Â h and the toxicity was further prolonged, as there was no complete recovery at 72Â h. These findings suggest a genotoxic effect of paraquat even after exposure via dermal application.
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Authors
Urban J.A. D'Souza, Anuar Zain, Sivachandra Raju,