Detailed review of transgenic rodent mutation assays

Based on the information and analyses in this review, there is sufficient evidence to support the recommendation that the OECD undertake the development of a Test Guideline on Transgenic Rodent Gene Mutation Assays. Accordingly, it is recommended that the OECD establish an Expert Working Group to develop such a Test Guideline, and serve as an international forum for undertaking any additional research that would lead to the development of a fuller understanding of the variables surrounding the conduct of TGR mutation assays.