Article ID Journal Published Year Pages File Type
9912215 Cytokine & Growth Factor Reviews 2005 18 Pages PDF
Abstract
Smad proteins are critical intracellular effector proteins and regulators of transforming growth factor type β (TGFβ) modulated gene transcription. They directly convey signals that initiate at ligand-bound receptor complexes and end in the nucleus with changes in programs of gene expression. Activated Smad proteins seem to recruit chromatin modifying proteins to target genes besides cooperating with DNA-bound transcription factors. We survey here the current and still emerging knowledge on Smad-binding factors, and their different mechanisms of chromatin modification in particular, in Smad-dependent TGFβ signaling.
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Life Sciences Biochemistry, Genetics and Molecular Biology Cell Biology
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