Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9912215 | Cytokine & Growth Factor Reviews | 2005 | 18 Pages |
Abstract
Smad proteins are critical intracellular effector proteins and regulators of transforming growth factor type β (TGFβ) modulated gene transcription. They directly convey signals that initiate at ligand-bound receptor complexes and end in the nucleus with changes in programs of gene expression. Activated Smad proteins seem to recruit chromatin modifying proteins to target genes besides cooperating with DNA-bound transcription factors. We survey here the current and still emerging knowledge on Smad-binding factors, and their different mechanisms of chromatin modification in particular, in Smad-dependent TGFβ signaling.
Keywords
SMADsilencing mediator for retinoid and thyroid receptorsR-SmadsDnmtSNOHP1CHDATP-utilizing chromatin assembly and remodeling factorHPEPRMTHoloprosencephalyTGIFLSD1CREBPARGPCAFRSCNuRDhMTSNFYY1CtBPRSFHKMTSNIPTRRAPtblGCN5BAFPEBP2CDKNCoREMSATSASucrose non-fermentingSUMOACFCHRACTGFβBrahma-related geneHIPK2HDACp300/CBP associated factorMTAMecp2MBDPARPAMLCBPbRGSMRTTLEAMTNURFNoRCAERDNA methyltransferaseSKIRemodelingTransforming growth factor βTrichostatin AsagaEvi-1lysine specific demethylase 1LATCore-binding factorArcapical ectodermal ridgeAcute myeloid leukaemiaBMPSignal transductionhistone deacetylaseHistonesprotein arginine methyltransferaseCREB binding proteinC-terminal binding proteinmethyl-CpG-binding protein 2cAMP-response element-binding proteinbone morphogenic proteinBone morphogenetic proteinheterochromatin protein 1Homeodomain-interacting protein kinase 2poly (ADP-ribose) polymeraseFatCHiPcyclin dependent kinasenuclear receptor co-repressorYin Yang 1
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Authors
Leo A. van Grunsven, Griet Verstappen, Danny Huylebroeck, Kristin Verschueren,