Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9912921 | Immuno-analyse & Biologie Spécialisée | 2005 | 5 Pages |
Abstract
NTproBNP has proved its power as an exclusion marker in diagnosis of congestive heart failure. In this study, from patients admitted to the Hospital of Cardiology, several factors determining in NTproBNP concentrations (age, sex, renal function and cardiac necrosis) were evaluated with proBNP assay on Elecsys 20.10 (Roche Diagnostics, Meylan, France). NTproBNP levels increase of 695Â ng/l (patients lower than 50Â years), to 2002 (more than 80Â years), of 622Â ng/l (patients without renal dysfunction) to 6278Â ng/l (severe renal insufficiency). These factors, as renal function, are crucial for NTproBNP results interpretation. From 39 echocardiography with LVEF measurements, at 250Â ng/l, cut-off excluding a cardiac dysfunction and at 1200Â ng/l with a high probability of heart failure, the negative predictive values of NTproBNP were respectively 100% and 85%. A negative correlation between LVEF and NTproBNP (RÂ =Â -0.38) was observed. Then, NTproBNP can be used in the screening of patients with left ventricular dysfunction, but its interpretation in diagnostic of heart failure needs to include factors like age, sex and renal function.
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Authors
C. Bionda, C. Bergerot, S. Cohen, C. Berny, D. Ardail, C. Rodriguez, R. Rousson,