| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9914874 | Molecular and Cellular Endocrinology | 2005 | 5 Pages |
Abstract
None of the compounds tested was cytotoxic in TE 671 cells, however, cell proliferation was significantly increased with 0.005-0.5 μM dioctyl phthalate, diisodecyl phthalate (DIP) and butylbenzyl phthalate (P < 0.05, n = 4). Real time RT-PCR showed dose-dependent decreases in steady-state mRNA levels of all the enzymes studied (P < 0.05, n = 4) with 0.005-0.5 μM octylphenol, bis (2-ethylhexyl) phthalate and DIP treatment. Endocrine disrupting effects of some plasticisers may be a consequence of modulation of expression of enzymes supplying PAPS for hormone sulphation.
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Authors
N. Turan, R.H. Waring, D.B. Ramsden,