Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9914879 | Molecular and Cellular Endocrinology | 2005 | 6 Pages |
Abstract
We have investigated the effects of bisphenol A (BPA) and BPA-dimethacrylate (BPA-DMA), endocrine disruptors used as plasticizers, on steroid hormone production by porcine ovarian granulosa cells after 72Â h incubation. BPA at 10â8Â M to 10â5Â M increased basal progesterone levels, while the same concentration range of BPA-DMA did not cause any changes. After FSH-stimulation of the cells, BPA-DMA showed a tendency to inhibit progesterone production. BPA, however, at 10â7Â M and 10â6Â M concentrations was even able to amplify FSH-stimulated progesterone synthesis. BPA as well as BPA-DMA inhibited FSH-induced estradiol production in the whole concentration range. LH-stimulated progesterone production was not altered by BPA in 10â8Â M to 10â5Â M, while BPA-DMA decreased progesterone levels in the cultured media. Significant inhibitory effect of both tested agents at 10â4Â M concentrations was observed specifically on progesterone production, basal as well as gonadotropin-stimulated. The results indicate that ovarian steroidogenesis might be one of the possible sites afflicted by the endocrine disrupting action of BPA and BPA-DMA.
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Authors
Alžbeta MlynarÄÃková, Jaroslav Kolena, Mária Ficková, SoÅa Scsuková,