| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9916333 | Seminars in Cell & Developmental Biology | 2005 | 11 Pages |
Abstract
The basic helix-loop-helix myogenic regulatory factors MyoD, Myf5, myogenin and MRF4 have critical roles in skeletal muscle development. Together with the Mef2 proteins and E proteins, these transcription factors are responsible for coordinating muscle-specific gene expression in the developing embryo. This review highlights recent studies regarding the molecular mechanisms by which the muscle-specific myogenic bHLH proteins interact with other regulatory factors to coordinate gene expression in a controlled and ordered manner.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cell Biology
Authors
Charlotte A. Berkes, Stephen J. Tapscott,