Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9920900 | European Journal of Pharmacology | 2005 | 10 Pages |
Abstract
The results of this study suggest an association between C3435T and G2677T MDR1 polymorphisms and transmembrane transport of some cytokines. Although the studied polymorphisms may be in linkage with polymorphisms of other transporters involved in cytokine release, it seems that the present results indirectly indicate involvement of P-glycoprotein in transport of some cytokines. Moreover, determination of C3435T and G2677T MDR1 polymorphisms might be useful in response prediction to therapy with methotrexate and dexamethasone.
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Authors
Andrzej Pawlik, Magdalena Baskiewicz-Masiuk, BogusÅaw Machalinski, Mateusz Kurzawski, Barbara Gawronska-Szklarz,