Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9920913 | European Journal of Pharmacology | 2005 | 5 Pages |
Abstract
Little research has been conducted investigating the long-term impact of opioid exposure during adolescence. These experiments were conducted to determine the behavioral effects of morphine exposure during periadolescence (postnatal days 30-32) versus young adulthood (postnatal days 65-67) on subsequent sensitivity to morphine. Male Sprague-Dawley rats were treated with three days of saline (S-S-S), one day of 10 mg/kg morphine followed by two days of saline (M-S-S), or three days of morphine (M-M-M). Unlike adult-treated counterparts, periadolescent M-M-M-treated rats showed greater locomotor response to morphine compared to S-S-S or M-S-S cohorts five weeks after treatment, suggesting age- and exposure-dependent differences in opioid sensitivity.
Keywords
Related Topics
Life Sciences
Neuroscience
Cellular and Molecular Neuroscience
Authors
David A. White, Stephen G. Holtzman,