Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9920914 | European Journal of Pharmacology | 2005 | 8 Pages |
Abstract
Our results demonstrate that myocardial protection can be achieved by calpain inhibition, which decreases infarct size and improves left ventricular contractility and global hemodynamic function. Hence, the calpain-calpastatin system might play an important pathophysiological role in porcine myocardial ischemia and reperfusion damage and A-705253 could be a promising cardioprotective agent.
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Authors
Philipe N. Khalil, Christiane Neuhof, Ralf Huss, Matthias Pollhammer, Maurice N. Khalil, Heinz Neuhof, Hans Fritz, Matthias Siebeck,