Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9920932 | European Journal of Pharmacology | 2005 | 8 Pages |
Abstract
This study used behavioural and in vivo electrophysiological paradigms to examine the effects of systemic and spinal administration of a bradykinin B1 receptor antagonist, compound X, on acute nociceptive responses in the rat. In behavioural experiments, compound X significantly increased the latency to withdraw the hindpaw from a radiant heat source after both intravenous and intrathecal administration, without affecting motor performance on the rotarod. In electrophysiological experiments, both intravenous and direct spinal administration of compound X attenuated the responses of single dorsal horn neurones to noxious thermal stimulation of the hindpaw. These data show that the antinociceptive effects of a bradykinin B1 receptor antagonist are mediated, at least in part, at the level of the spinal cord and suggest a role for spinal bradykinin B1 receptors in acute nociception.
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Authors
Rachel K. Conley, Alan Wheeldon, Janine K. Webb, Robert M. DiPardo, Carl F. Homnick, Mark G. Bock, Tsing-Bau Chen, Raymond S.L. Chang, Douglas J. Pettibone, Susan Boyce,