| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9920991 | European Journal of Pharmacology | 2005 | 4 Pages |
Abstract
To obtain further insight into the interactions between the N-methyl-d-aspartate receptor and opioid receptor systems, we have investigated the effects of the acute treatment of morphine on the expression of serine racemase and d-amino acid oxidase mRNAs in several brain areas of rats. The morphine administration produced a dose-dependent and transient elevation in the levels of serine racemase and d-amino acid oxidase mRNAs in all the brain areas. The present results are the first to suggest an interaction between the expression of the mRNAs for the d-serine-related enzymes and the opioid receptor activation.
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Authors
Masanobu Yoshikawa, Hidehiro Andoh, Kenji Ito, Toshiyasu Suzuki, Mitsuru Kawaguchi, Hiroyuki Kobayashi, Tetsuo Oka, Atsushi Hashimoto,