Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9921027 | European Journal of Pharmacology | 2005 | 6 Pages |
Abstract
Chymase is a chymotrypsin-like serine protease that is stored exclusively in the secretory granules of mast cells and converts big endothelins to endothelin-1 (1-31). The aim of this study was to evaluate the effect of chymase on intraocular pressure in rabbits. Chymase injection (3 and 10 mU) resulted in a trend toward increased intraocular pressure and a significant increase in intraocular pressure at a dose of 10 mU compared with the control. A specific chymase inhibitor, Suc-Val-Pro-PheP(OPh)2, attenuated the ocular hypertension induced by chymase. Endothelin-1 (1-31) also caused ocular hypertension, which was inhibited by a selective endothelin ETA receptor antagonist, cyclo(D-Asp-Pro-D-Val-Leu-D-Trp) (BQ-123). Moreover, chymase-induced ocular hypertension was inhibited by BQ-123. These results suggest that chymase influences the regulation of intraocular pressure, and it is likely that the formation of endothelin-1 (1-31) and subsequent activation of endothelin ETA receptors are involved in the development of ocular hypertension induced by chymase.
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Authors
Takashi Konno, Midori Maruichi, Shinji Takai, Hidehiro Oku, Tetsuya Sugiyama, Takehiro Uchibori, Akihiko Nagai, Kentaro Kogi, Tsunehiko Ikeda, Mizuo Miyazaki,