| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9921045 | European Journal of Pharmacology | 2005 | 4 Pages |
Abstract
The function of the γ-aminobutyric acidB (GABAB) receptor, measured as baclofen-stimulated [35S]GTPγS binding, was evaluated in some brain regions of Sardinian alcohol-preferring (sP) and -nonpreferring (sNP) rats. EC50 value of baclofen-stimulated [35S]GTPγS in limbic areas was approximately 125% higher in alcohol-naive sP than sNP rats; voluntarily consumed alcohol reduced the EC50 value to a level similar to that of alcohol-naive sNP rats. These results suggest the presence of a genetically determined lower function of the GABAB receptor in limbic areas of sP than sNP rats; this differential functioning of the GABAB receptor may contribute to the opposite preference for alcohol in these rat lines.
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Authors
M. Paola Castelli, Fabio Pibiri, A. Paola Piras, Giovanni Carboni, Alessandro Orrù, Gian Luigi Gessa, Mauro A.M. Carai, Giancarlo Colombo,