Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9921084 | European Journal of Pharmacology | 2005 | 5 Pages |
Abstract
Contrary to the cyclic nucleotide-gated channel, the f-channel is not directly modulated by Ca2+-calmodulin. The data suggest that W7 alters the voltage-dependent properties of If independent of cAMP binding. This agent opens the pathway for a new family of bradycardic drugs.
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Authors
Aurélien Chatelier, Barbara Renaudon, Jocelyn Bescond, Antoun El Chemaly, Marie Demion, Patrick Bois,